What Is Esketamine (Spravato®)?
Esketamine is the S-enantiomer of ketamine delivered as a nasal spray under physician supervision. Unlike SSRIs or SNRIs, it targets the brain’s glutamate system (the NMDA receptor ) to enhance neuroplasticity. Many patients experience meaningful symptom relief in hours to days rather than weeks.
Proven, Rapid Results
In a Phase 3 randomized trial of adults with major depressive disorder and active suicidal ideation, esketamine plus standard care produced significantly greater improvement on the MADRS depression scale at 4–24 hours compared with placebo plus standard care, with benefits maintained during the 4-week acute phase.
- Clinically meaningful improvement by 4 hours
- Statistically significant benefit at 24 hours
- Common effects are transient (e.g., dizziness, brief dissociation, mild ↑BP)
Esketamine is FDA-approved for Treatment-Resistant Depression and for MDD with suicidal thoughts or behavior. Treatment occurs only in certified clinics under the REMS program.
Who Is It For?
- Treatment-Resistant Depression(after ≥2 adequate antidepressant trials)
- MDD with suicidal thoughts or behavior needing rapid symptom reduction
- Adults seeking evidence-based, rapid-acting depression treatment in Florida
What to Expect at Florida TMS Clinic
- Private, comfortable treatment room with continuous monitoring
- Self-administered Spravato® nasal spray under clinician supervision
- Each visit ~ 2 hours including observation and recovery
- Typical schedule: twice weekly during the acute phase, then taper
- No driving until the next day after each session
- Used alongside an oral antidepressant for stability and durability
Safety & Monitoring
We follow all REMS safety requirements. Blood pressure and comfort are monitored throughout. Most temporary effects resolve within 1–2 hours.
If you’re in immediate crisis, call 988 (Suicide & Crisis Lifeline) or 911.
Esketamine in Tampa & Wesley Chapel
Florida TMS Clinic — Tampa
Convenient to South Tampa, Downtown, and Westshore. Same-week evaluations often available.
Florida TMS Clinic — Wesley Chapel
Serving Wesley Chapel, New Tampa, Lutz, Land O’ Lakes, and North Tampa communities.
Take the First Step Toward Relief
If you’re searching for Esketamine in Tampa or Spravato treatment in Wesley Chapel, our team can help you find rapid relief with a personalized plan that may also include TMS and psychotherapy when appropriate.
Esketamine (Spravato®) — FAQs
- How fast does Esketamine work?
- Many patients notice improvement in mood symptoms within hours to days. In clinical trials, significant benefits were seen as early as 4 hours and at 24 hours.
- Who is a candidate for Spravato®?
- Adults with treatment-resistant depression (after at least two antidepressants) or those with major depression and suicidal thoughts or behavior.
- Is Esketamine covered by insurance?
- Coverage varies by plan and indication. Our team verifies benefits and will help navigate prior authorization whenever possible.
- What are common side effects?
- Transient dizziness, brief dissociation, nausea, and temporary blood-pressure increases. We monitor you throughout every visit.
- Can I drive after treatment?
- No. Plan for a safe ride home and avoid driving until the next day after each session.
References: Ionescu DF et al., Int J Neuropsychopharmacology, 2021; Spravato® Prescribing Information (Janssen).
