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Both TMS and ECT are indicated for Treatment Resistant depression. Both TMS and ECT aim at stimulating the brain to induce therapeutic neuromodulation in the brain circuits. TMS uses magnetic field pulses, while ECT does it by delivering electrical “shock” directly. As magnetic stimulation can go through the skull without intentionally causing a seizure, TMS has none of the side effects associated with ECT. In this article, we will discuss the similarity and differences. You can refer to the comparison table for easy side by side review.
What's the success rate of TMS? Click here to learn more.
TMS stands for
Transcranial Magnetic Stimulation. Other terminologies and subtypes used for TMS are repetitive transcranial magnetic stimulation, intermittent theta burst stimulation, deep transcranial magnetic stimulation, and
accelerated transcranial magnetic stimulation.
ECT stands for Electro-Convulsive Therapy. Other terminologies used for ECT are electrical shock therapy or shock therapy.
TMS, as per Faraday’s law, electrical fields can induce electrical current and vice versa. In TMS, an electrical current runs in pulses into a coil of wires. This will generate a targeted magnetic field. When pointed directly at a specific area of the brain, this magnetic field will induce small electrical activation of the target brain cells, which leads to the desired effect. Typically, there are no side effects of this activation. A seizure is indeed very rare to happen (1/30,000) and is considered an undesirable side effect.
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how TMS works
ECT uses electricity directly and diffusely. A powerful electrical current is run through the skull diffusely through the brain leading to an electrical activation. This leads to the desired effects and sometimes undesired ones (memory loss). Because electrical shock is painful, patients need to be under full sedation during the treatment. The electrical shock produces a therapeutic seizure for about 1-3 minutes.
TMS is currently FDA approved for the indications of depression, OCD, and smoking cessation. It is commonly used for anxiety, PTSD, fibromyalgia, insomnia, and other mental and neurological disorders.
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conditions treated with TMS
ECT is indicated for resistant depression, resistant psychosis, bipolar, catatonia, and neuroleptic malignant syndrome.
TMS is done in an out-patient setting. This means that TMS is done in a doctor’s office. TMS doesn’t require anesthesia, and patients are fully awake during the treatment. Patients can drive themselves before and after the treatment.
ECT is done in a hospital. This is because it requires general anesthesia. Patients will need to be monitored for a couple of hours after they wake up from sedation. A family member needs to be around to drive them back home.
TMS is ordered and supervised by a psychiatrist. The treatments are delivered by a TMS technician trained in utilizing the
TMS machine.
TMS can result in a seizure, but this side effect is scarce (1/30,000). TMS can cause scalp discomfort and/or headache. Hearing protection is required during TMS to prevent hearing loss or ringing from the machine’s tapping noise.
ECT aims to induce a therapeutic seizure, so we can’t call this a side effect. A seizure might last longer than desired, which can be dangerous. Anesthesia carries cardiopulmonary event risk (1/10,000). ECT can result in memory loss. In most cases, it is for short-term memory; in others, it could be long-term memory loss.
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pros and cons of TMS therapy
TMS | ECT |
---|---|
Transcranial Magnetic Stimulation | Electroconvulsive Therapy |
Magnetic pulses | Electrical shock |
Depression, OCD, Smoking | Depression, Bipolar, Psychosis, Catatonia, NMS |
Done at a doctor’s office | Done at a hospital |
No sedation needed | Done under full sedation |
Side effects: Low risk of seizure, mild temporary scalp discomfort | Side effects: Headache, Memory Loss, Risks of anesthesia (including death) |
Magnezi R, Aminov E, Shmuel D, Dreifuss M, Dannon P. Comparison between neurostimulation techniques repetitive transcranial magnetic stimulation vs electroconvulsive therapy for the treatment of resistant depression: patient preference and cost-effectiveness. Patient Prefer Adherence. 2016 Aug 4;10:1481-7. doi: 10.2147/PPA.S105654. PMID: 27536079; PMCID: PMC4977067.
Chen JJ, Zhao LB, Liu YY, Fan SH, Xie P. Comparative efficacy and acceptability of electroconvulsive therapy versus repetitive transcranial magnetic stimulation for major depression: A systematic review and multiple-treatments meta-analysis. Behav Brain Res. 2017 Mar 1;320:30-36. doi: 10.1016/j.bbr.2016.11.028. Epub 2016 Nov 19. PMID: 27876667.
George MS, Nahas Z, Li X, Kozel FA, Anderson B, Yamanaka K, Chae JH, Foust MJ. Novel treatments of mood disorders based on brain circuitry (ECT, MST, TMS, VNS, DBS). Semin Clin Neuropsychiatry. 2002 Oct;7(4):293-304. doi: 10.1053/scnp.2002.35229. PMID: 12382211.
Yuan S, Tirrell E, Gobin AP, Carpenter LL. Effect of Previous Electroconvulsive Therapy on Subsequent Response to Transcranial Magnetic Stimulation for Major Depressive Disorder. Neuromodulation. 2020 Apr;23(3):393-398. doi: 10.1111/ner.13046. Epub 2019 Oct 6. PMID: 31588659; PMCID: PMC7131879.
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